Edited by experts from one of the world's largest leukemia
centers, this book provides information on the biology of the
variety of leukemic disorders, up-to-date diagnostic testing and
many new developments in therapy. Chapters covering new treatments
present an outlook for the future and explain the rationale for
ongoing clinical trials.
Topics include:
* Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora
kinase inhibitors, kit inhibitors, BCR-ABL inhibitors)
* Ras inhibitors
* Epigenetic therapy (hypomethylaters and histone deacetylase
inhibitors)
* Lenalidomide analogs
* New chemotherapy drugs, e.g. clofarabine, cloretazine,
sapacitabine, forodesine
* Combinations of chemotherapy with kinase inhibitors (e.g. ALL
induction protocols in combination with dasatinib or imatinib)
* New monoclonal antibodies (lumiliximab, humaxCD20,
anti-CD40)
* Thrombopoietic agents
Leukemias: Principles and Practice of Therapy
* Includes practical information to guide you in challenging
situations, such as treatment of elderly patients, pregnancy,
relapsed and refractory disease
* Incorporates chapters on supportive care and pharmacologic
information about the most frequently used drugs in this area
